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Association between postmenopausal vulvovaginal discomfort, vaginal microbiota, and mucosal inflammation

Dr. Susan Reed

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Mission

We conduct clinical, epidemiologic, and translational research to improve the lives of women with reproductive endocrine conditions.  Our work focuses on mitigating the impact of distress related to infertility, menopause, puberty, uterine fibroids, adenomyosis, endometriosis, and polycystic ovarian syndrome, and understanding the factors that cause these conditions so that we may target physiologic pathways with our interventions. We support the reproductive autonomy of individuals and expanding access to quality reproductive health services. Through our research, we strive to generate high-impact science and promote health equity and justice with the goal of improving the lives and health of women and their families around the world.

Notable Achievements

  • Evaluated the KNDy neuron complex in the hypothalamus. Manipulating this neuron complex holds great promise for amelioration of menopausal symptoms.
  • Established that IVM oocytes are deficient in glutathione and identified a novel supplement to increase oocyte glutathione levels, promote normal fertilization and improve embryo development.
  • Generated employed gene-editing strategies to develop FMR1 knock-out ESC lines as a cellular model of Fragile-X disorders

Principal Investigators

Eliza Curnow, PhD

Eliza Curnow, PhD

Research Interests: gamete biology & embryology reproductive toxicology model development embryonic stem cells
Networks & Centers: Contraline Inc, Washington National Primate Research Center, Florida State University, Oncofertility Consortium
Bibliography 

Hamazaki

Nobuhiko Hamazaki, PhD

Research Interests: mammalian germ cell development, early embryonic development, genomics and system biology
Centers & Networks: Department of Genome Sciences, ISCRM, BBI

Website & Bibliography

 

Susan Reed, MD

Susan Reed, MD

Research Interests: reproductive hormone impacts on midlife women's health, 
Centers & Networks: MsFLASH
Bibliography

Ginny Ryan, MD, MA

Ginny Ryan, MD, MA

Research Interests: reproductive bioethics, access to care, emerging reproductive technologies, conceptualizations of infertility, social and environmental determinants of health
Centers & Networks: 
Bibliography

Robert Steiner, PhD

Robert Steiner, PhD

Research Interests: neuroendocrinology, reproductive endocrinology, hormonal regulation of neuropeptide genes, hypothalamic neural circuitry; neurobiology of menopausal hot flashes, gene targeting; in situ hybridization; immunocytochemistry
Centers & Networks:
Bibliography

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Lucia Vojtech, PhD

Research Interests: Immune tolerance to pregnancy, sexually transmitted infections, reproductive and mucosal immunology
Centers & Networks: Extracellular RNA Communication Consortium, The Human Placenta Project

Bibliography

 

Yang

Min Yang, PhD

Research Interests: stem cell differentiation and organoids, synthetic embryogenesis, disease modeling, reproductive and maternal-fetal medicine, regenerative medicine

Website Bibliography