Association between postmenopausal vulvovaginal discomfort, vaginal microbiota, and mucosal inflammation

Dr. Susan Reed recently authored "Association between postmenopausal vulvovaginal discomfort, vaginal microbiota, and mucosal inflammation", published in the American Journal of Obstetrics and Gynecology. To read more, please follow the link below.

Mission: We conduct clinical, epidemiologic, and translational research to improve the lives of women with reproductive endocrine conditions.  Our work focuses on mitigating the impact of distress related to infertility, menopause, puberty, uterine fibroids, adenomyosis, endometriosis, and polycystic ovarian syndrome, and understanding the factors that cause these conditions so that we may target physiologic pathways with our interventions. We support the reproductive autonomy of individuals and expanding access to quality reproductive health services. Through our research, we strive to generate high-impact science and promote health equity and justice with the goal of improving the lives and health of women and their families around the world.


Notable achievements

  • Evaluated the KNDy neuron complex in the hypothalamus. Manipulating this neuron complex holds great promise for amelioration of menopausal symptoms.
  • Established that IVM oocytes are deficient in glutathione and identified a novel supplement to increase oocyte glutathione levels, promote normal fertilization and improve embryo development.
  • Generated employed gene-editing strategies to develop FMR1 knock-out ESC lines as a cellular model of Fragile-X disorders

Meet the Principal Investigators

Curnow

 

Eliza Curnow, PhD
Research Interests: gamete biology & embryology reproductive toxicology model development embryonic stem cells
Networks & Centers: Contraline Inc, Washington National Primate Research Center, Florida State University, Oncofertility Consortium
Bibliography

 


 

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Susan Reed, MD
Research Interests: reproductive hormone impacts on midlife women's health, 
Centers & Networks: MsFLASH
Bibliography

 


 

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Ginny Ryan, MD, MA
Research Interests: reproductive bioethics, access to care, emerging reproductive technologies, conceptualizations of infertility, social and environmental determinants of health
Centers & Networks: 
Bibliography

 


 

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Robert Steiner, PhD
Research Interests: neuroendocrinology, reproductive endocrinology, hormonal regulation of neuropeptide genes, hypothalamic neural circuitry; neurobiology of menopausal hot flashes, gene targeting; in situ hybridization; immunocytochemistry
Centers & Networks:
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VojtechLucia Vojtech, PhD
Research Interests: How does semen influence infectious disease and immunity in the female genital tract? Does semen contribute to tolerance to pregnancy, pre-conception? Can we use biomarkers in blood to diagnose the risk of developing pre-eclampsia during pregnancy? What does a protective immune response to Chlamydia infection look like? How can we design an effective vaccine against Chlamydia? Does opioid use change sperm and eggs? Is it possible that opioid use affects future generations?
Centers & Networks: Extracellular RNA Communication Consortium,
                                             The Human Placenta Project
                                             Bibliography